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AKC Canine Health Foundation Research Update – Grant 1787 

Apr 10, 2016

Here is the most recent research summary for Grant 1787 which the NCA Charitable Trust has co-sponsored.

The full scientific progress report has been reviewed and approved.

If scientific publications are listed, you may access these articles online by searching for the articles through PubMed (pubmed.gov) or through Google Scholar (scholar.google.com).  Depending on the journal, the publication may be open access or it may be purchased for a fee.  Due to copyright laws, CHF is unable to widely distribute electronic copies that we receive.

On behalf of the all of us here at AKC CHF, thank you for your continued and generous support of canine health research.

Samantha Wright – Program Manager

PDF Summary – Grant 1787

Research on SAS continuing at UC-Davis by Dr. Joshua Stern

Dec 1, 2015

Dr. Stern and Stern Cardiac Genetics Lab continue their research into SAS in many breeds including Newfoundlands. The CTMB continues to support research in our Newfoundland dogs. His lab needs samples from clear and SAS affected Newfoundlands to continue their research. We are asking for samples to help Dr. Stern continue his research that is so important to the future health of our Newfoundlands. The criterion for sample submission follows.

Dr. Stern: The key to identifying additional mutations or disease modifier genes is to have a large sample database. Unfortunately, despite many reports of new affected dogs, I have not been receiving very many fresh samples.   The following is what we need to put dogs into our research program:

1.) An EDTA (purple top blood tube – kept refrigerated after drawn) of blood (2-3ml)

2.) A 3-generation pedigree

3.) An echocardiography report from a veterinary cardiologist (this needs to include the measurements from the cardiologist)

We would love to have samples from both affected and normal Newfoundlands. If a breeder has an affected puppy and they could send closely related relatives and their respective echo reports, pedigrees and blood samples, this would also help.

For examples, if Puppy A is affected, the unaffected brother or parents would also be quite valuable for the study. However, all animals enrolled need to have items 1-3 above included with their shipment.

Samples can be shipped to:

Stern Cardiac Genetics Lab

UC Davis

2108 Tupper Hall

Davis CA 95616

Any questions regarding shipments, sample receipt or eligibility can be forwarded to my lab manager at esontiveros@ucdavis.edu or by calling the lab at 530-752-4892.

Study Update – Abnormalities in the Stomach’s Ability to Contract Predisposes Large-Breed Dogs to Bloat

Jun 14, 2015

We have made significant process in the completion of this project in 2014.
completed sampling of all unaffected Great Danes and 50% of our desired number of affected Great Danes. In addition, we have enrolled the majority of our WT controls and are beginning to contact and enroll Weimaraners and Bloodhounds, with plans to complete enrollment and sampling in spring and summer of 2015.

Results of motility evaluation at this time are preliminary, but we are observing a relationship between low fasting gastric pH and some breeds. Further sampling will help to demonstrate if this relationship is important. Use of the SmartPill wireless motility device has produced excellent studies. As we have enrolled only a small number of the GDV survivors of all breeds, we are looking forward to seeing what features of gastric motility are most common in GDV survivors. This will help us recognize if similar patterns are present at higher or lower levels in the other populations that we are evaluating.

At this time, evaluation of the relationship between GDV, GDV risk, and breed and blood levels of motilin and ghrelin (hormones that help to regulate gastric movement in the fasting state) is ongoing.

Finally, we have completed candidate gene analysis for MLN and GHRL, the genes for the motilin and ghrelin hormones, in the Great Dane. At this time, it appears that a mutation of these genes is NOT associated with GDV risk in the Great Dane.